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Kazuhisa Takahashi Selected Research

Gefitinib (Iressa)

1/2022Randomized Phase III Study of Gefitinib Versus Cisplatin Plus Vinorelbine for Patients With Resected Stage II-IIIA Non-Small-Cell Lung Cancer With EGFR Mutation (IMPACT).
1/2021Zinc-finger E-box-binding homeobox 1 (ZEB1) plays a crucial role in the maintenance of lung cancer stem cells resistant to gefitinib.
10/2020Gefitinib Alone Versus Gefitinib Plus Chemotherapy for Non-Small-Cell Lung Cancer With Mutated Epidermal Growth Factor Receptor: NEJ009 Study.
11/2019Role of FBXW7 in the quiescence of gefitinib-resistant lung cancer stem cells in EGFR-mutant non-small cell lung cancer.
11/2017A method of high-throughput functional evaluation of EGFR gene variants of unknown significance in cancer.
7/2016Gefitinib in the treatment of nonsmall cell lung cancer with activating epidermal growth factor receptor mutation.
4/2016Oct4 plays a crucial role in the maintenance of gefitinib-resistant lung cancer stem cells.
1/2016Diagnostic significance of cerebrospinal fluid EGFR mutation analysis for leptomeningeal metastasis in non-small-cell lung cancer patients harboring an active EGFR mutation following gefitinib therapy failure.
8/2015The effect of gefitinib in patients with postoperative recurrent non-small cell lung cancer harboring mutations of the epidermal growth factor receptor.
1/2014Hypoxia increases gefitinib-resistant lung cancer stem cells through the activation of insulin-like growth factor 1 receptor.
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Kazuhisa Takahashi Research Topics

Disease

119Pain (Aches)
01/2019 - 04/2002
66Neoplasms (Cancer)
02/2022 - 04/2002
57Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)
03/2022 - 01/2005
44Low Back Pain (Lumbago)
06/2021 - 04/2004
38Inflammation (Inflammations)
11/2022 - 04/2002
30Lung Neoplasms (Lung Cancer)
10/2021 - 02/2006
29Hyperalgesia
01/2017 - 01/2002
21Neoplasm Metastasis (Metastasis)
12/2021 - 09/2002
19Lymphangioleiomyomatosis (Lymphangiomyomatosis)
01/2021 - 01/2008
17Intervertebral Disc Degeneration
04/2018 - 10/2006
16Neuralgia (Stump Neuralgia)
01/2021 - 01/2007
15Asthma (Bronchial Asthma)
07/2021 - 01/2007
14Interstitial Lung Diseases (Interstitial Lung Disease)
11/2021 - 10/2008
14Spinal Cord Injuries (Spinal Cord Injury)
01/2016 - 07/2009
14Intervertebral Disc Displacement (Herniated Disc)
10/2014 - 09/2004
13Disease Progression
03/2022 - 11/2007
12Infections
11/2022 - 10/2008
12Chronic Obstructive Pulmonary Disease (COPD)
11/2018 - 12/2012
12Osteoporosis
01/2018 - 01/2005
11Lung Diseases (Lung Disease)
01/2021 - 09/2006
11Hypoxia (Hypoxemia)
10/2020 - 10/2008
11Spinal Stenosis (Stenosis, Spinal)
06/2020 - 06/2011
10Scoliosis
05/2021 - 01/2009
10Pathologic Constriction (Stenosis)
01/2018 - 01/2007
9Dyspnea (Shortness of Breath)
01/2020 - 03/2006
9Pneumonia (Pneumonitis)
10/2019 - 04/2012
8Adenocarcinoma of Lung
11/2021 - 01/2015
8Knee Osteoarthritis
11/2017 - 10/2009
8Osteoarthritis
01/2017 - 02/2010
7Cachexia
02/2022 - 01/2008
7Thymoma (Thymic Carcinoma)
01/2022 - 01/2009
7Adenocarcinoma
01/2021 - 12/2008
7Idiopathic Pulmonary Fibrosis
01/2021 - 01/2019
7Small Cell Lung Carcinoma (Small Cell Lung Cancer)
01/2020 - 11/2009
7Spondylolisthesis
01/2018 - 01/2009
7Back Pain (Backache)
01/2018 - 05/2010
7Ganglion Cysts (Ganglion)
08/2013 - 08/2006
6Pulmonary Emphysema
01/2022 - 09/2006
6Cysts
01/2021 - 06/2012
6Carcinoma (Carcinomatosis)
01/2021 - 02/2006
6Hip Osteoarthritis (Coxarthrosis)
12/2020 - 10/2012
6Spinal Cord Diseases
08/2020 - 03/2012
6Fibrosis (Cirrhosis)
01/2020 - 10/2009
6Congenital Abnormalities (Deformity)
01/2018 - 07/2010
6Wounds and Injuries (Trauma)
12/2016 - 08/2011
5Pleural Effusion (Pleural Effusions)
01/2022 - 01/2007
5COVID-19
01/2022 - 01/2021

Drug/Important Bio-Agent (IBA)

39CytokinesIBA
02/2022 - 04/2002
30Calcitonin Gene-Related PeptideIBA
10/2018 - 04/2004
29Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
02/2022 - 05/2004
25Nerve Growth Factor (NGF)IBA
10/2018 - 04/2004
23Biomarkers (Surrogate Marker)IBA
10/2021 - 09/2002
21ErbB Receptors (EGF Receptor)IBA
12/2021 - 05/2011
20lipoarabinomannan (LAM)IBA
01/2021 - 01/2007
19salicylhydroxamic acid (SHAM)IBA
03/2018 - 07/2005
18Tyrosine Kinase InhibitorsIBA
06/2022 - 03/2014
17NeuropeptidesIBA
10/2018 - 10/2009
15Adrenal Cortex Hormones (Corticosteroids)IBA
07/2021 - 10/2006
15Proteins (Proteins, Gene)FDA Link
01/2020 - 02/2006
14Gefitinib (Iressa)FDA Link
01/2022 - 12/2008
12Pharmaceutical PreparationsIBA
06/2022 - 09/2013
12SteroidsIBA
11/2021 - 07/2011
12Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
01/2018 - 04/2002
10Peptides (Polypeptides)IBA
01/2022 - 08/2005
10AntibodiesIBA
01/2022 - 09/2006
10Interleukin-6 (Interleukin 6)IBA
06/2017 - 05/2011
10Granulocyte Colony-Stimulating Factor (G-CSF)IBA
01/2016 - 01/2012
10OsteopontinIBA
04/2011 - 04/2002
8Analgesics (Analgesic Drugs)IBA
07/2017 - 01/2012
8Nerve Growth Factor Receptor (Nerve Growth Factor Receptor, Low Affinity)IBA
10/2015 - 12/2004
7Immune Checkpoint InhibitorsIBA
02/2022 - 03/2016
7Cisplatin (Platino)FDA LinkGeneric
01/2022 - 01/2009
7SmokeIBA
01/2022 - 09/2006
7EnzymesIBA
05/2021 - 09/2006
7Transforming Growth Factors (Transforming Growth Factor)IBA
07/2020 - 11/2012
7Freund's AdjuvantIBA
03/2017 - 01/2002
6B7-H1 AntigenIBA
02/2022 - 06/2020
6Tumor Biomarkers (Tumor Markers)IBA
01/2022 - 01/2005
6Phosphotransferases (Kinase)IBA
10/2021 - 12/2010
6InterleukinsIBA
07/2021 - 01/2007
6Pemetrexed (MTA)FDA Link
01/2021 - 12/2012
6Monoclonal AntibodiesIBA
05/2019 - 09/2006
6Activating Transcription Factor 3IBA
10/2018 - 08/2008
6Lidocaine (Xylocaine)FDA LinkGeneric
01/2016 - 08/2006
6methanesulfonate salt 2-hydroxy-4,4'-diamidinostilbeneIBA
12/2015 - 12/2006
6MesothelinIBA
10/2014 - 09/2006
6LectinsIBA
10/2008 - 04/2004
5pembrolizumabIBA
02/2022 - 01/2019
5Prednisolone (Predate)FDA LinkGeneric
11/2021 - 01/2009
5MethylprednisoloneFDA LinkGeneric
08/2021 - 10/2008
5nintedanibIBA
01/2021 - 01/2019

Therapy/Procedure

62Therapeutics
01/2022 - 10/2006
25Drug Therapy (Chemotherapy)
03/2022 - 01/2004
15Pedicle Screws
01/2018 - 01/2005
14Decompression
06/2020 - 05/2010
13Aftercare (After-Treatment)
11/2021 - 08/2009
13Spinal Fusion (Spondylosyndesis)
01/2018 - 03/2010
11Conservative Treatment
01/2016 - 01/2008
6Transplantation
01/2016 - 10/2009
6Osteotomy
01/2016 - 10/2012